Hydrogen therapy from the initiation to its practical applications

Molecular hydrogen (H 2 ) has emerged as a therapeutic and prophylactic agent devoid of adverse effects. H 2 demonstrates multifaceted functionality across diverse cell types and organs, attributable to its interaction with oxidized hemes as a fundamental molecular mechanism. Given the abundance of various heme types both intracellularly and extracellularly, the broad-ranging effects of H 2 are comprehensible. Subsequent Pathways are mediated by end-or modified- products of lipid peroxide followed by free radical chain reactions. Notably, H 2 confers benefits not only to patients afflicted with diseases but also to individuals seeking to enhance health and wellness. The mission of hydrogen medicine encompasses addressing unresolved medical challenges, including cerebral infarction, post-cardiac arrest syndrome, advanced cancer, metabolic syndrome, and dementia. Transitioning from animal experiments to clinical studies is imperative to confront these formidable diseases effectively.