A Comprehensive Review on the Self-Nanoemulsifying System for the Delivery of Herbal Drugs

: Self-Nanoemulsifying Drug Delivery Systems (SNEDDSs) are an isotropic mixture of oils, co-surfactants, and surfactants and can form fine O/W nanoemulsions in aqueous media. These components are advantageous in terms of improved solubility and bioavailability, as limited permeability, solubility, and bioavailability remain a significant challenge in the development of herbal drugs. This review explores the potential of self-nanoemulsifying drug delivery systems (SNEDDSs) as a promising strategy to overcome this problem. The SNEDDSs are considered to be a novel technique for the delivery of low water-soluble drugs. They can bypass the first-pass metabolism, which ultimately results in steady and sustained drug levels in the systemic circulation. The present article provides a comprehensive overview of the SNEDDSs formulation of herbal drugs. It includes their composition, characterization, in vitro and in vivo studies conducted on various disease conditions, and their pharmacokinetic studies.