封堵器
结肠炎
右旋糖酐
化学
脂多糖
双歧杆菌
炎症性肠病
免疫球蛋白A
双歧杆菌
抗体
势垒函数
免疫球蛋白G
免疫系统
促炎细胞因子
肠道菌群
紧密连接
免疫学
生物化学
炎症
医学
乳酸菌
内科学
生物
疾病
发酵
细胞生物学
作者
Chunxu Chen,Junhua Xu,Tianxiang Han,Guijie Chen,Kaiyuan Yu,Chenyu Du,Wenbiao Shen,Yi Sun,Xiaoxiong Zeng
标识
DOI:10.1021/acs.jafc.3c07733
摘要
Sialylated immunoglobulin G (IgG) is a vital glycoprotein in breast milk with the ability to promote the growth of Bifidobacterium in gut microbiota and relieve inflammatory bowel disease (IBD) symptoms in vitro. Here, it was found that the microcapsules with sialylated IgG could protect and release sialylated IgG with its structure and function in the intestine. Furthermore, the sialylated IgG microcapsules alleviated the clinical symptoms (body weight, feed quantity, and colon length loss), decreased disease activity index score, suppressed the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β, IFN-γ, and MCP-1) and endotoxin (lipopolysaccharide), and enhanced the intestinal mucosal barrier (Claudin1, Muc2, Occludin, and ZO-1) in dextran sulfate sodium (DSS)-induced colitis mice. Additionally, the sialylated IgG microcapsules improved the gut microbiota by increasing the relative abundance of critical microbe Bifidobacterium bifidum and promoted the production of short-chain fatty acids (SCFAs). Correlation analysis indicated that the key microbes were strongly correlated with pro-inflammatory factors, clinical symptoms, tight junction protein, and SCFAs. These findings suggest that the sialylated IgG microcapsules have the potential to be used as a novel therapeutic approach for treating IBD.
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