兰克尔
中性粒细胞胞外陷阱
骨吸收
炎症
细胞生物学
先天免疫系统
细胞外
髓样
骨重建
化学
免疫系统
免疫学
生物
受体
内分泌学
生物化学
激活剂(遗传学)
作者
Kento Numazaki,Hiroyuki Tada,Takashi Nishioka,Eiji Nemoto,Kazunobu Matsushita,Itaru Mizoguchi,Shunji Sugawara
标识
DOI:10.1016/j.bbrc.2024.149743
摘要
Neutrophil extracellular traps (NETs) released by neutrophils upon inflammation or infection, act as an innate immune defense against pathogens. NETs also influence inflammatory responses and cell differentiation in host cells. Osteoclasts, which are derived from myeloid stem cells, are critical for the bone remodeling by destroying bone. In the present study, we explores the impact of NETs, induced by the inflammatory agent calcium ionophore A23187, on the differentiation and activation of osteoclasts, potentially through suppressing RANK expression. Our results collectively suggested that the inhibition of RANKL-mediated osteoclastogenesis by NETs might lead to the suppression of excessive bone resorption during inflammation.
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