[Research Progress of Carboxymethyl Chitosan-Based Haemostatic Materials and Their Haemostatic Mechanism --Review].

Effective haemostatic materials can quickly control bleeding and achieve the purpose of saving patients' lives. In recent years, chitosan-based haemostatic materials have shown good haemostatic effects, but their application is limited because chitosan is almost insoluble in water. Carboxymethyl chitosan-based haemostatic materials can promote hemostasis by activating red blood cells and aggregating platelets. In addition, carboxymethyl chitosan can bind with Ca2+ to activate platelets and coagulation factors, and start endogenous coagulation pathways, which can adsorb fibrinogen in plasma to promote haemostasis. In this paper, the latest research progress of carboxymethyl chitosan-based haemostatic materials and their haemostatic mechanism were reviewed, in order to further strengthen the understanding of the haemostatic mechanism of carboxymethyl chitosan-based haemostatic materials, and provide new idea for the research and clinical application of carboxymethyl chitosan-based haemostatic materials.羧甲基壳聚糖基止血材料及其止血机制的研究进展..有效的止血材料可以快速控制出血，达到拯救患者生命的目的。近年来新型止血材料中壳聚糖基止血材料具有较好的止血效果，但由于壳聚糖几乎不溶于水，限制了其应用。羧甲基壳聚糖基止血材料可以通过对红细胞的活化、诱导血小板聚集来促进止血。此外，羧甲基壳聚糖可与Ca2+结合，活化血小板并激活凝血因子，启动内源性凝血途径，可吸附血浆中的纤维蛋白原，促进止血。本文对羧甲基壳聚糖基止血材料及其止血机制的最新研究进展作一综述，旨在进一步加强对羧甲基壳聚糖基止血材料止血机制的认识，为羧甲基壳聚糖基止血材料的研发及临床应用提供新思路。.