A Magnetically Actuated Neural Probe for Multi‐Focal Location in Epilepsy

Abstract Intractable epilepsy often requires the use of stereo‐electroencephalography (SEEG) for localizing the epileptic focus. However, SEEG is associated with high invasiveness and relatively limited localization accuracy. This study presents a novel magnetically actuated neural probe (MANP) that integrates remote magnetic navigation and multimodal sensing capabilities to achieve precise localization of epileptic foci. MANP can controllably navigate and accurately target the potential regions of epileptic foci through a single surgical microhole under magnetic actuation. Equipped with multimodal biosensors, MANP tracks EEG signals and neurotransmitter levels (dopamine and hydrogen peroxide) in real‐time, providing detailed insights into abnormal brain activities. In vivo experiments with epileptic rats, MANP detected elevated levels of dopamine and hydrogen peroxide alongside high‐frequency (4–30 kHz) EEG signals at seizure onset. It effectively identifies multiple suspicious lesions via a single skull entry point under magnetic navigation, distinguishing epileptic from normal brain regions. Therefore, MANP enables minimal invasion, remote magnetic navigation, multi‐modal detection, and multi‐focal localization, providing a versatile platform for the precise localization of epileptic foci and potential treatment of other neurological disorders.