Multidisciplinary Treatment of Pancreatic Neuroendocrine Neoplasm with Portal Vein Thrombosis and Multiple Liver Metastases by Minimally Invasive Surgical and Neoadjuvant Therapy: A Case Report

The treatment of patients with pancreatic neuroendocrine neoplasms accompanied by metastasis is complex and highly individualized. This article reports a 43-year-old male patient diagnosed with a neuroendocrine tumor on the pancreatic tail combined with portal vein thrombosis and multiple liver metastases. After multidisciplinary diagnosis and treatment, the patient underwent 6 months of neoadjuvant chemotherapy (CAPTEM), followed by laparoscopic distal pancreatectomy and splenectomy, portal vein thrombectomy and reconstruction, and partial hepatectomy in October 2023. The patient recovered well postoperatively, and the pathological results confirmed a neuroendocrine tumor (G2) with negative resection margins. This case highlights the importance of multidisciplinary treatment in the management of pancreatic neuroendocrine tumors and the effectiveness of surgical intervention, providing a reference for the diagnosis and treatment of similar cases.