Biomimetic Transformation of Inferior Parenchyma Cellulose into a Sustainable, Functional Medical Hydrogel Inspired by the Dermis

Abstract Inevitable daily damage to skin necessitates advanced occlusive dressings to mitigate infections and accelerate regeneration. Biomacromolecule‐based hydrogels serve as sustainable alternatives to synthetic polymers, facing challenges in achieving multifunctional integration. To address this issue, a novel multifunctional biomass‐derived hydrogel is developed which exhibits characteristics such as stretchability, adhesiveness, moisture absorption capacity, drug loading/sustained release, and antibacterial properties. The gel is developed through synergistic interactions among bamboo‐derived regenerated cellulose (RC), carboxylated β‐cyclodextrin (Hβ‐CD), silanized liquid metal nanodroplets (SLM NDs), and pectin. This composite forms a 3D network stabilized by hydrogen, ionic, and amide bonds, exhibiting exceptional stretchability (247.7%), adhesiveness (7.81–23.97 kPa), and toughness (4.47 MJ m −3 ). Its microporous structure efficiently absorbs wound exudates; while, maintaining an optimal healing microenvironment. Host–guest interactions between Hβ‐CD and benzalkonium chloride (BKC) enhance drug‐loading capacity, achieving 78.8% sustained release. Antibacterial assays demonstrate inhibition zones against E. coli (20.07 ± 1.57 mm) and S. aureus (32.21 ± 0.34 mm). In vivo studies reveal 75% wound closure rate within 10 days. SLM NDs enable dynamic reversible bonds for mechanical adaptability; while, pectin reinforces bioadhesion and structural integrity. These properties make this hydrogel a promising candidate for clinical wound care, offering significant potential for medical applications.