Polymeric micelles for drug codelivery

Polymeric micelles (PMs) have shown promising potential in multidrug codelivery and in the treatment of cancer. The potential of PMs has been further improved by fine-tuning their characteristics for precise targeting of tumors, controlled or sequential drug release, and enhanced cellular uptake. Although much has been done in the areas of drug targeting, their controlled release, and cellular uptake, more consideration is needed to improve synergistic therapeutic results and minimalize side effects. This chapter offers a comprehensive summary of numerous PMs used for the codelivery of drugs. These PMs possess potential to release the coloaded drugs either sequentially or simultaneously by using exclusive tumor microenvironment characteristics such as elevated local temperature, overexpressed enzyme, redox and acidic pH, and external environmental triggers. Limitations and future perspectives of these PMs for codelivery have also been discussed here.