Asymmetric Nickel-Catalyzed Denitrogenative Transannulation to Construct Axially Chiral C–N Atropisomers

Here, we report an enantioselective nickel-catalyzed transannulation reaction through a denitrogenative strategy for the synthesis of new atropisomers under mild conditions. A series of axially chiral atropisomers bearing a chiral C-N bond were achieved with excellent enantioselectivities and regioselectivities. Moreover, a broad range of alkynes and 1,2,3-benzotriazinones were well tolerated by this method. The possible mechanism further reveals the role of nickel and the enantioselectivity control.