三萜类
化学
柱色谱法
色谱法
乙醇
硅胶
传统医学
植物
立体化学
生物
生物化学
医学
作者
Zhenhai Han,Jia-Tong Wu,Yuxuan Lin,Yu B,Anam Naseem,Zhichao Hao,Juan Pan,Wei Guan,Hai‐Xue Kuang,Qingshan Chen,Lili Zhang,Yan Liu,Bing‐You Yang
出处
期刊:Fitoterapia
[Elsevier]
日期:2024-06-01
卷期号:175: 105902-105902
标识
DOI:10.1016/j.fitote.2024.105902
摘要
Seven new triterpenoids, named Adeterpenoids A-G (1-7) and eight known compounds (8-15), were isolated from 70% ethanol extract of the roots of Adenophora tetraphylla (Thub.) Fisch. The compounds from it were separated by column chromatography techniques such as silica gel, ODS, and preparative liquid chromatography. Their structures were clarified based on extensive spectral analysis (1D, 2D-NMR, HR-ESI-MS, IR, UV, and CD) and comparison with the literature. At the same time, all compounds were evaluated for their cytotoxic activity against the LN229 (human glioma cell line). The results showed that compounds 2, 5, 6, 13, and 14 had a significant inhibitory effect on LN229 cells.
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