骨桥蛋白
非酒精性脂肪肝
脂肪肝
脂肪变性
纤维化
炎症
医学
CD36
癌症研究
内分泌学
免疫学
内科学
疾病
受体
作者
Hui Han,Xiaodong Ge,Sai Santosh Babu Komakula,Romain Désert,Sukanta Das,Zhuolun Song,Wei Chen,Dipti Athavale,Harriet Gaskell,Daniel D. Lantvit,Grace Guzman,Natalia Nieto
标识
DOI：10.1053/j.gastro.2023.03.228
摘要
MF-derived OPN protects from NASH, by upregulating OSM, which increases ARG2 through STAT3 signaling. Further, the ARG2-mediated increase in FAO reduces steatosis. Therefore, enhancing the OPN-OSM-ARG2 crosstalk between MFs and hepatocytes may be beneficial for patients with NASH.
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(2025-6-4)
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