Location of colon cancer (right-sided versus left-sided) as a prognostic factor and a predictor of benefit from cetuximab in NCIC CO.17

西妥昔单抗 医学 克拉斯 内科学 结直肠癌 肿瘤科 危险系数 比例危险模型 表皮生长因子受体 脾曲 耐火材料(行星科学) 胃肠病学 癌症 置信区间 结肠镜检查 生物 天体生物学
作者
Stephanie Yasmin Brule,Derek J. Jonker,Christos S. Karapetis,Chris O’Callaghan,Malcolm J. Moore,Ralph Wong,Niall C. Tebbutt,C.R. Underhill,Desmond Yip,John Zalcberg,Dongsheng Tu,Rachel Goodwin
出处
期刊:European Journal of Cancer [Elsevier]
卷期号:51 (11): 1405-1414 被引量:273
标识
DOI:10.1016/j.ejca.2015.03.015
摘要

Right- and left-sided colon cancers (RC, LC) differ with respect to biology, pathology and epidemiology. Previous data suggest a mortality difference between RC and LC. We examined if primary tumour side also predicts for outcome in chemotherapy refractory, metastatic colon cancer (MCC). We also compared RC versus LC as a predictor of efficacy of epidermal growth factor receptor (EGFR) inhibition with cetuximab.Reanalyzing NCIC CO.17 trial (cetuximab versus best supportive care [BSC]), we coded the primary tumour side as RC (caecum to transverse colon) or LC (splenic flexure to rectosigmoid). The association between tumour side and baseline characteristics was assessed. Cox regression models determined factors affecting overall survival (OS) and progression free survival (PFS).Patients with RC (150/399) had more poorly differentiated, mutant KRAS, mutated PIK3CA and wild-type BRAF tumours, fewer liver and lung metastases, and shorter interval between diagnosis and study entry. Among BSC patients, tumour side was not prognostic for PFS (hazard ratios (HR) 1.07 [0.79-1.44], p = 0.67) or OS (HR 0.96 [0.70-1.31], p = 0.78). Among wild-type KRAS patients, those with LC had significantly improved PFS when treated with cetuximab compared to BSC (median 5.4 versus 1.8 months, HR 0.28 [0.18-0.45], p < 0.0001), whereas those with RC did not (median 1.9 versus 1.9 months, HR 0.73 [0.42-1.27], p = 0.26), [interaction p = 0.002].In refractory MCC, tumour location within the colon is not prognostic, but is strongly predictive of PFS benefit from cetuximab therapy. Additional research is needed to understand the molecular differences between RC and LC and their interaction with EGFR inhibition.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
9秒前
天天快乐应助听弦采纳,获得10
9秒前
慕青应助科研通管家采纳,获得10
11秒前
shinysparrow应助科研通管家采纳,获得10
11秒前
Hello应助科研通管家采纳,获得10
11秒前
shinysparrow应助科研通管家采纳,获得10
11秒前
11秒前
11秒前
11秒前
小蘑菇应助根根采纳,获得10
11秒前
13秒前
jc哥发布了新的文献求助10
13秒前
冷酷的半莲完成签到,获得积分10
13秒前
加油呀发布了新的文献求助30
14秒前
FLYQRF发布了新的文献求助10
17秒前
1254完成签到,获得积分10
20秒前
21秒前
朴素便当应助懵懂小尉采纳,获得20
22秒前
水晶茶杯发布了新的文献求助10
23秒前
Daylight发布了新的文献求助200
23秒前
23秒前
24秒前
根根发布了新的文献求助10
26秒前
听弦发布了新的文献求助10
29秒前
夏侯乌发布了新的文献求助10
30秒前
雪山飞狐发布了新的文献求助10
31秒前
32秒前
科目三应助秋心泉采纳,获得10
35秒前
37秒前
jc哥完成签到,获得积分20
38秒前
雪山飞狐完成签到,获得积分10
41秒前
41秒前
慎ming发布了新的文献求助10
43秒前
追寻完成签到,获得积分10
45秒前
46秒前
v小飞侠101发布了新的文献求助10
47秒前
慎ming完成签到,获得积分10
48秒前
48秒前
壮观绝悟完成签到,获得积分10
49秒前
50秒前
高分求助中
Teaching Social and Emotional Learning in Physical Education 900
Chinese-English Translation Lexicon Version 3.0 500
[Lambert-Eaton syndrome without calcium channel autoantibodies] 440
Plesiosaur extinction cycles; events that mark the beginning, middle and end of the Cretaceous 400
Two-sample Mendelian randomization analysis reveals causal relationships between blood lipids and venous thromboembolism 400
薩提亞模式團體方案對青年情侶輔導效果之研究 400
3X3 Basketball: Everything You Need to Know 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2386515
求助须知:如何正确求助?哪些是违规求助? 2092963
关于积分的说明 5266585
捐赠科研通 1819823
什么是DOI,文献DOI怎么找? 907766
版权声明 559181
科研通“疑难数据库(出版商)”最低求助积分说明 484897