Mechanochemical Synthesis of CD‐MOFs and Application as a Cosmetic Ingredient

The cyclodextrins (CDs) are widely used in food, pharmaceutical, textile, and cosmetic industries. The CD macrocycles can be applied in various fields by coordinating with metals to synthesize coordination polymers. In this study, cyclodextrin‐metal–organic frameworks (CD‐MOFs) were successfully synthesized using two different methods for the reaction between cyclodextrin and potassium. The structural identities of the CD‐MOF‐a and CD‐MOF‐b synthesized by two methods were confirmed through 1H NMR, powder X‐ray diffraction, and FTIR measurements. In addition, substances, such as ferulic acid, salicylic acid, and so on, that were difficult to use as cosmetic ingredients due to their water insolubility, were easily encapsulated within CD‐MOFs, and the resulting amounts of loading were determined using 1H NMR, FT‐IR, and HPLC analyses.