Background: Neonatal sepsis is one of the major causes of morbidity and mortality in the newborn. Early diagnosis and treatment are crucial in the management of neonatal sepsis. Blood culture, the gold standard, takes long time and lack sensitivity. Hematological sepsis score is a simple score obtained by combining routinely available tests and is rapid, non-expensive and has shown good correlation with blood culture. With this background the study was carried out to evaluate hematological changes in neonatal sepsis and to analyse the diagnostic utility of hematological scoring system (HSS) and its correlation with C-reactive protein and blood culture in neonatal sepsis.