不育
肥胖
医学
瘦素
男性不育
吻素
生育率
氧化应激
激素
炎症
生物信息学
内科学
内分泌学
生理学
生物
怀孕
人口
环境卫生
遗传学
作者
Hamed Heydari,Rafighe Ghiasi,Saber Ghaderpour,Rana Keyhanmanesh
出处
期刊:Current Diabetes Reviews
[Bentham Science]
日期:2021-03-01
卷期号:17 (3): 259-267
被引量:13
标识
DOI:10.2174/1573399816666200819114032
摘要
Introduction: Obesity resulted by imbalance between the intake of energy and energy consumption can lead to growth and metabolic disease development in people. Both in obese men and animal models, several studies indicate that obesity leads to male infertility. Objective: This review has discussed some mechanisms involved in obesity-induced male infertility. Method: Online documents were searched through Science Direct, Pubmed, Scopus, and Google Scholar websites dating from 1959 to recognize studies on obesity, kisspeptin, leptin, and infertility. Results: Obesity induced elevated inflammatory cytokines and oxidative stress can affect male reproductive functions, including spermatogenesis disorders, reduced male fertility power and hormones involved in the hypothalamus-pituitary-gonadal axis. Conclusion: There is significant evidence that obesity resulted in male infertility. Obesity has a negative effect on male reproductive function via several mechanisms such as inflammation and oxidative stress.
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