[Overview of Staphylococcus aureus mobile genetic elements and horizontal gene transfer of antimicrobial resistance genes].

The mechanism of antimicrobial resistance transmission mediated by mobile genetic elements (MGEs) in Staphylococcus aureus is highly complicated, leading a significant challenge for controlling the spread of the resistant Staphylococcus aureus strains. Based on the latest literature acquired in this work, we have overviewed the transmission mechanism of antimicrobial resistance encoding MGEs. It is notably that there are a number of MGEs, which may encode different antimicrobial resistance determinants and possess specific transmission mechanism. In spite of this specificity of the strains to their host (human or animal), some Staphylococcus aureus strains can be transmitted from animals to humans or vice versa. This ability of cross staphylococci transfer is an additional means to acquire new genetic material encoded by MGE. It was suggested in this review that study on transmission mechanism of MGEs mediated antimicrobial resistance genes could provide important biological information of their spreading and effectively help prevent and control of the resistant strains and/or resistance genes among human, animals and ecologies.金黄色葡萄球菌可移动遗传元件介导的耐药传播机制复杂，给耐药性防控带来重大挑战。本文结合国内外最新文献，综述了金黄色葡萄球菌抗生素耐药传播相关的可移动遗传元件及其传播机制研究进展。金黄色葡萄球菌编码耐药基因的可移动遗传元件种类繁多，不同的可移动遗传元件编码耐药基因不尽相同，其传播机制也具有特异性，人和动物来源的金黄色葡萄球菌可移动遗传元件存在显著差异，金黄色葡萄球菌可移动遗传元件可在人和动物间交互传递，因此又存在一定的趋向性。可通过研究金黄色葡萄球菌耐药基因随可移动遗传元件扩散的传播机制，解析可移动遗传元件转移过程重要的生物学信息，有效防控金黄色葡萄球菌耐药性在动物、人类和环境中的传播。.