抗菌肽
免疫学
自身免疫
先天免疫系统
自身免疫性疾病
免疫系统
银屑病
免疫
关节炎
抗菌剂
类风湿性关节炎
获得性免疫系统
发病机制
疾病
医学
生物
抗体
微生物学
病理
作者
Ekaterina S. Umnyakova,Maria S. Zharkova,Mikhail N. Berlov,O. V. Shamova,V. N. Kokryakov
出处
期刊:Autoimmunity
[Informa]
日期:2020-01-08
卷期号:53 (3): 137-147
被引量:17
标识
DOI:10.1080/08916934.2020.1711517
摘要
Antimicrobial peptides (AMPs) were firstly discovered as cytotoxic substances that killed bacteria. Later they were described as biologically active peptides that are able not only to kill invaders but also to modulate host immunity. In particular, it is shown that human antimicrobial peptides are able to influence the activity of different innate and adaptive immunity components, thus, obviously, they also participate in autoimmune processes. In this review we discuss the nature of human AMPs and analyze their role in such autoimmune disorders like type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and sarcoidosis. These peptides were shown to have a “double-sided” influence on the autoimmune disease pathogenesis. Thus, described facts should be taken into account for the development of new pharmaceutical agents to cure patients with autoimmune disorders. These agents could derive from natural antimicrobial peptides that in some cases modulate immune response. For example, it was shown that human AMPs are able to modulate complement system dysregulation of which is known to be one of the most dangerous pathogenic factors during autoimmune processes.
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