炎症
氧化应激
药理学
化疗
医学
体内
消炎药
癌症
免疫学
外科
内科学
生物
生物技术
作者
Shi-Feng Lai,Ruotong Liu,Wen-Hui Peng,Xiaoting Huang,Xicheng Wang,Jiayi Qian,Wenjie Mei,Miao Cheng,Teng Wang,Baoguo Wang
标识
DOI:10.1016/j.ejphar.2020.173571
摘要
Chemotherapy drugs exerts beneficial antitumor activity before and after cancer surgery. Post-injury complications are a potential hazard after surgical tumor resection. Inflammation caused by surgical stress is known to promote the progression of post-injury complications. Recent studies have found that chemotherapy drugs can promote post-injury inflammatory response, leading to increased post-injury complications. Imidazole derivatives have effective anticancer activity. However, the impact of post-operative inflammation caused by imidazole derivatives is unclear. In this study, two novel phenanthroimidazole derivatives (L082 and L142) were synthesized and characterized. These compounds showed significant inhibitory effects on different tumor cells. The compound L082 also inhibited liver cancer in vivo. In addition, L082 played a significant role in inhibiting the accumulation of inflammatory cells and promoting the elimination of inflammatory cells at the incision, which may be related to inhibiting the production of ROS and NO in oxidative and nitric stress. These results suggest that L082 can be used as a bifunctional drug to suppress tumors and reduce post-injury inflammation complications.
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