免疫学
免疫系统
抗原
生物
免疫疗法
癌症
免疫
医学
癌症研究
接种疫苗
癌症疫苗
内科学
作者
Gal Cafri,Jared J. Gartner,Tal Zaks,Kristen Hopson,Noam Levin,Biman C. Paria,Maria R. Parkhurst,Rami Yossef,Frank J. Lowery,Mohammad Jafferji,Todd D. Prickett,Stephanie L. Goff,Christine T. McGowan,Samantha J. Seitter,Mackenzie L. Shindorf,Anup Y. Parikh,Praveen D. Chatani,Paul F. Robbins,Steven A. Rosenberg
摘要
BACKGROUND. Therapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have thus far resulted in little clinical benefit. Studies conducted by multiple groups have demonstrated that T cells recognizing neoantigens are present in most cancers and offer a specific and highly immunogenic target for personalized vaccination.
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