Estimation of Procollagen Type III Peptide (PIIIP) Level in β Thalassemia Patients

Procollagen type III peptide (PIIIP) is established as biochemical markers of liver fibrosis. So that, type III (Pro-C3) can be used as diagnostic tools for liver fibrosis. Collagen type III amino-terminal pro-peptide (PIIINP) is a degradation product of collagen type III, the increase of which may reflect an ongoing fibrotic process. Procollagen type III is found abundantly in skeletal muscle and other soft tissues such as skin, and in negligible amounts in bone. During the late phases of collagen synthesis, the N-terminal end of procollagen type III is cleaved releasing P3NP into the circulation. According to case-control study. This study was conducted with eighty-eight of males that age ranges from 2–29 years, which divided in 60 of males with β-thalassemia whom have visited the Thalassemia Center at Al-Zahraa Teaching Hospital in Al-Najaf province, Iraq, for managed of the disease, and 28 voluntary healthy as a control groups of. The study was carried out from January 2018 to July 2018., Procollagen type III in β-thalassemic patients and healthy groups of males. It also investigates the relationship between these biomarkers levels was measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA) and also, determined Hb, Body Mass Index, splenic status liver function test (ALT, ASTand ALP).