席夫碱
化学
生物高聚物
核化学
热稳定性
高分子化学
金属
配体(生物化学)
热重分析
结晶度
壳聚糖
无机化学
有机化学
结晶学
生物化学
聚合物
受体
作者
Murugaiyan Manimohan,Rajakkani Paulpandiyan,Sivashanmugam Pugalmani,Mohamed Aboobucker Sithique
标识
DOI:10.1016/j.ijbiomac.2020.06.278
摘要
In this study, the new N, N, O tridentate donor water soluble isoniazid based biopolymer Schiff base ligand and their Co (II), Cu (II), Zn (II) metal complexes were prepared. The compounds were designed for potential biological application such as antibacterial, antifungal, anti-inflammatory, total antioxidant, antidiabetic and DNA binding studies. The synthesized compounds were illuminated in different light sources of various spectra were used to explore the functional groups of Biopolymer derivatives. Thermal degradation, thermal stability and percentage of mass loss for the prepared compounds were investigated through thermo gravimetric and differential thermal (TGA-DTA) analyses. Crystalline structure of synthesized biopolymer derivatives were explored by X-ray diffraction (XRD) studies, the crystallinity of chitosan is gradually decreased after the Schiff base and complex formation. Surface morphology and structures of the prepared compounds were examined using SEM analysis. The magnetic moment and magnetism of the metal complexes were studied using Vibrating-sample magnetometer (VSM). Antidiabetic studies of Biopolymer Schiff base and metal complexes were carried out by α-amylose inhibitory method. DNA nuclease activities of synthesized metal complexes were investigated by Ultra-Violet (UV) and viscometry methods. The Cu (II) complexes showed better DNA binding results than Co (II) and Zn (II) complexes.
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