FOXP3型
免疫学
免疫系统
RAR相关孤儿受体γ
发病机制
红斑狼疮
医学
系统性红斑狼疮
刺激
周边公差
外周血
T细胞
内分泌学
内科学
抗体
疾病
作者
Cen Jiang,Huaizhou Wang,Minghui Xue,Lin Lin,Jianbiao Wang,Gang Cai,Qian Shen
标识
DOI:10.1016/j.clim.2019.108267
摘要
Treg is essential to limit the extend and duration of the immune response, but its stability is still under debate. Here we demonstrate that IL-17-producing Treg cells (Th17-like cells) increased in peripheral blood of patients with Systemic Lupus Erythematosus (SLE). Notably, the Th17-like cells from patient with active SLE were characterized with some phenotype and function of Th17 cells. Upon stimulation, Helios-Foxp3 + CD4+ T cells decrease Foxp3 expression but increase expression of IL-17 and RORγt. Damage associated molecule pattern and inflammatory cytokines are important for induction of IL-17 expression in Treg cells. The Th17-like cells from patients with active SLE lose suppressive function and have robust response to stimulation of autoantigens. We also observed that the level of Th17-like cells in peripheral blood is closely associated with the clinical index of SLE. These findings suggest that instability of Treg plays a critical role in pathogenesis of autoimmune diseases.
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