Progress in plasmid-mediated colistin resistance gene mcr-1

Colistin has been revalued as the last resort for multi-drug resistant gram-negative bacteria infections and attracted considerable attention. The plasmid-mediated colistin resistance gene mcr-1 was first reported in 2005, which not only altered our understanding of the mechanisms of colistin resistance, but also posed a significant threat to public health. Until now, mcr-1 has been reported in more than 30 countries and regions spreading over five continents. The whole world has paid high attention to mcr-1 and taken measures to control the administration of colistin in order to contain the spread and dissemination of mcr-1. This review focused on the structure, epidemiology and molecular biological characteristics of mcr-1 and measures for the prevention of mcr-1 spreading, aiming at enhancing the recognition, prevention and control of mcr-1. Key words: Colistin; mcr-1; plasmid; Antimicrobial resistance