粘蛋白
医学
乳腺癌
人体乳房
乳腺
癌症
病理
乳腺肿瘤
跨膜蛋白
肿瘤科
内科学
受体
作者
Rana Vafaei,Mitra Samadi,Aysooda Hosseinzadeh,Khadijeh Barzaman,MohammadReza Esmailinejad,Zohreh Khaki,Leila Farahmand
标识
DOI:10.1186/s12935-021-02398-6
摘要
Abstract Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breast cancer mechanisms, canine mammary tumors (CMTs) could be used as a spontaneously occurring tumor model for human studies. Accordingly, this review assessed the comparison of canine and human MUC-1 based on their diagnostic and therapeutic aspects and showed how comparative oncology approaches could provide insights into translating pre-clinical trials from human to veterinary oncology and vice versa which could benefit both humans and dogs.
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