Anti-Diabetic Action of Polyherbal Ethanolic Extract in Alloxan-induced Diabetes in Wistar Rats

Background: Diabetes mellitus is a complex chronic metabolic disease with heterogeneous etiology and risk factors at the social level and behavioral, environmental, and genetic susceptibility. There are numerous traditional medicinal plants reported having hypoglycemic properties, such as Allium sativum (Garlic), Azadirachta indica (Neem), Punica granatum (Anar), Trigonella foenum (Fenugreek), Momordica charantia (Bitter gourd), and Ocimum sanctum (Tulsi). The use and delivery of herbal medicine as a dosage form in treating and preventing diseases has a long history started with use in Mesopotamia in 2600 B.C. However, the oldest record on the practice of medicinal plants for drug preparation was engraved on a Sumerian clay slab, created over 5,000 years ago. The use of medicinal plants is continuing in this modern era, and it has been estimated that approximately one-fourth of prescription medicines worldwide are derived from plants. Objective: The present study was carried out to evaluate the anti-diabetic effects of Ethanolic extract of leaves of Punica granatum, Beta vulgaris, and Azadirachta Indica in alloxan-induced diabetic rats. The use of herbal products is not only limited to dietary uses, such as food, nutrition, etc., but it also has a distinct role in the remedy of several diseases. Methods: Animals were induced with diabetes using Alloxan and then were observed on the basis of numerous parameters to access the induction and control of diabetes in comparison to all groups. The animal received dosing of Herbal extracts in treated groups and was checked for Fasting blood glucose. Neurobehavioral studies and the weight of all animals were checked on 7, 14, 21, 28 days after induction of diabetes. Results: The results proved that the herbal extract of the powder was anti-diabetic in action. Conclusion: The herbal extract must be tested for the phytoconstituents, and the active constituent must be isolated to perform research on humans.