材料科学
微尺度化学
纳米技术
微流控
生物分子
复合数
纳米颗粒
拉曼散射
等离子体子
聚合物
拉曼光谱
光电子学
复合材料
光学
物理
数学教育
数学
作者
Nikunjkumar Visaveliya,Raminta Mazetyte‐Stasinskiene,J. Michael Köhler
标识
DOI:10.1002/adom.202102757
摘要
Abstract Surface‐enhanced Raman scattering (SERS) is a label‐free and accurate analytical technique for the detection of a broad range of various analytes such as, biomolecules, pesticides, petrochemicals, as well as, cellular and other biological systems. A key component for the SERS analysis is the substrate which is required to be equipped with plasmonic features of metal nanostructures that directly interact with light and targeted analytes. Either metal nanoparticles can be deposited on the solid support (glass or silicon) which is suitable for stationary SERS analysis or dispersed in the solution (freely moving nanoparticles). Besides these routinely utilizing SERS substrates, polymer–metal composite particles are promising for sustained SERS analysis where metal nanoparticles act as plasmon‐active (hence SERS‐active) components and polymer particles act as support to the metal nanoparticles. Composite sensor particles provide 3D interaction possibilities for analytes, suitable for stationary, continuous, and sequential analysis, and they are reusable/regenerated. Therefore, this review is focused on the experimental procedures for the development of multiscale, uniform, and reproducible composite sensor particles together with their application for SERS analysis. The microfluidic reaction technique is highly versatile in the production of uniform and size‐tunable composite particles, as well as, for conducting SERS analysis.
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