下调和上调
离子通道
未折叠蛋白反应
心力衰竭
医学
心肌梗塞
蛋白激酶A
药理学
激酶
心脏病学
内科学
化学
细胞生物学
内质网
生物
受体
生物化学
基因
作者
Man Liu,Guolian Kang,Samuel C. Dudley
标识
DOI:10.1016/j.molmed.2022.03.006
摘要
Cardiomyopathies are associated with arrhythmias and cardiac ion channel downregulation. This downregulation is arrhythmogenic. Paradoxically, antiarrhythmic therapies are based on ion channel-blocking drugs that further downregulate these channels and exhibit proarrhythmic risk. Recent studies have shown that inhibition of the protein kinase RNA-like ER kinase (PERK) arm of the unfolded protein response (UPR) prevents select cardiac ion channel downregulation and plays a protective role against arrhythmias. Prevention of ion channel downregulation represents as a novel therapeutic strategy to treat arrhythmias in myocardial infarction and heart failure.
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