化学
胺化
亚胺离子
均分解
区域选择性
组合化学
胺气处理
环胺
硝基苯
卤素
自由基离子
极地的
氢原子
光化学
激进的
有机化学
离子
催化作用
烷基
物理
天文
作者
Wongyu Lee,Dong-Wook Kim,Sangwon Seo,Sukbok Chang
标识
DOI:10.1002/anie.202202971
摘要
Herein, we report a polar-radical relay strategy for α-C-H amination of cyclic amines with N-chloro-N-sodio-carbamates. The relay is initiated by in situ generation of cyclic iminium intermediate using N-iodosuccinimide (NIS) oxidant as an initiator, which then operates through a series of polar (addition and elimination) and radical (homolysis, hydrogen- and halogen atom transfer) reactions to enable the challenging C-N bond formation in a controlled manner. A broad range of α-amino cyclic amines were readily accessed with excellent regioselectivity, and the superb applicability was further demonstrated by functionalization of biologically relevant compounds.
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