脂样坏死
医学
糖尿病
组织病理学
病理
棘皮病
皮肤病科
角化过度
内分泌学
作者
Emma F. Johnson,Meera H. Patel,Caitlin M. Brumfiel,Kevin J. Severson,Puneet Bhullar,Blake Boudreaux,Richard J. Butterfield,David J. DiCaudo,Sara Nelson,Mark R. Pittelkow,Aaron R. Mangold
摘要
Necrobiosis lipoidica (NL) is an uncommon granulomatous dermatosis that can occur in patients with or without associated diabetes mellitus (DM). Prior studies have attempted to determine distinctive histopathologic features of NL in patients with and without DM.A retrospective review of 97 patients with NL was performed to determine the similar and distinctive histopathologic features in patients with DM and without DM.Of the 97 patients, 32% (n = 31) had DM. Epidermal acanthosis was seen more commonly in diabetics than nondiabetics (32.3% vs. 12.1%; p = 0.017). Naked (sarcoidal/tuberculoid) granulomas were more frequently observed in nondiabetics than diabetics (22.7% vs. 3.2%; p = 0.016). Eosinophils were more common in nondiabetics than diabetics (38.5% vs. 9.7%; p = 0.004), while neutrophilic infiltration was more common in diabetics than nondiabetics (45.2% vs. 17.5%; p = 0.004).This study corroborates well-documented histopathologic features of NL and shows distinctive histopathologic features of NL among patients with DM-I, DM-II, and without DM. These results support the hypothesis that there are different underlying drivers of NL between diabetics and nondiabetics.
科研通智能强力驱动
Strongly Powered by AbleSci AI