毛花素
芒柄花素
根(腹足类)
黄芪
胃
汉方
化学
色谱法
黄芪甲苷
医学
传统医学
高效液相色谱法
内科学
病理
生物
中医药
大豆黄酮
染料木素
替代医学
植物
作者
Xiaohua Liu,Zhixin Xue,Bo Wang,Ying Wang,Mengting Zhang,Shilan Feng
出处
期刊:Brazilian Journal of Pharmaceutical Sciences
[SciELO]
日期:2022-01-01
卷期号:58
被引量:1
标识
DOI:10.1590/s2175-97902022e18524
摘要
Numerous studies have demonstrated that Radix Astragali can inhibit gastric ulcers in mice. Anhydrous ethanol (0.01 mL/g) administered to mice by intragastric infusion can induce gastric ulcer injury. This study was performed to compare the stomach tissue distribution profiles of four major bioactive constituents of Radix Astragali(calycosin-7-O-β-d-glucoside, calycosin, ononin and formononetin) after oral administration of extract of Radix Astragali (ERA)in normal and gastric ulcer mice. The abundance of Radix Astragali constituents was determined using an ultra-pressure liquid chromatograph with a photodiode array detector (UPLC-PDA), after which histograms were drawn. In comparison with normal mice, the contents of calycosin- 7-O-β-d-glucoside, calycosin, ononin and formononetin in the stomach tissue samples of gastric ulcer mice showed significant differences at the selected time points (P < 0.05).The abundance of each of the four tested constituents in the normal groups was higher than that of the gastric ulcer groups. This study provides an empirical foundation for future studies focused on developing clinical applications of Radix Astragali.
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