The Relationship Between Helicobacter pylori and Reflux Esophagitis(A Case - Control Study)

Purpose To identify the relationship betw een Helicobacter pylori and reflux esophagitis. Methods A case-control study was designed.Among 20 128 patients who accepted gastroscopic examination from March 2002 to Feb. 2004.Tho se 641 patients with reflux esophagitis were included in the case group,and 64 1 controls were selected from the same population by matching sex,age and endosc opic examination date.The Helicobacter pylori infection positive status of e ach patient was determined by positive result of either the rapid urease test or Gimsa staining. Results The rate of reflux esophagitis was 3.18% (641/2 0 128).The Helicobacter pylori positive rate was significantly lower in the case group (39.8%) than in the control group (45.7%,OR:0.785,95%CI:0.629-0.979 ) . Conclusions Helicobacter pylori infection may decre ase the occurrence of reflux esophagitis.