B细胞激活因子
CD38
医学
免疫学
B细胞
系统性红斑狼疮
内科学
免疫系统
红斑狼疮
抗体
CD19
内分泌学
疾病
生物
遗传学
干细胞
川地34
作者
Diana Celeste Salazar-Camarena,Pablo César Ortiz‐Lazareno,Álvaro Cruz,Edith Oregón-Romero,Jesús René Machado-Contreras,José Francisco Muñóz-Valle,Mariana Orozco-López,Miguel Marín‐Rosales,Claudia Azucena Palafox‐Sánchez
出处
期刊:Lupus
[SAGE]
日期:2015-09-29
卷期号:25 (6): 582-592
被引量:101
标识
DOI:10.1177/0961203315608254
摘要
B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) signaling pathways regulate B-cell survival through interactions with their receptors BAFF-R, TACI and BCMA. We evaluated the association of these ligands/receptors on B-cell subsets according to clinical manifestations of systemic lupus erythematosus (SLE).BAFF and APRIL serum concentrations were measured in 30 SLE patients by enzyme-linked immunosorbent assay. The BAFF-R, TACI and BCMA expression was analyzed on each B cell subset (CD19 + CD27-CD38-/ + naïve; CD19 + CD27 + CD38-/ + memory; CD19 + CD27-CD38 + + immature and CD19 + CD27 + CD38 + + plasma cells) by flow cytometry, and compared among patients with different clinical manifestations as well as healthy controls (HCs).Serum BAFF and APRIL levels were high in SLE patients and correlated with the Mex-SLEDAI disease activity index (r = 0.584; p = 0.001 and r = 0.456; p = 0.011, respectively). The SLE patients showed an increased proportion of memory and plasma B cells (p < 0.05). BAFF-R, TACI and BCMA expression in SLE patients was decreased in almost all B cell subsets compared to HCs (p < 0.05). A lower BCMA expression was associated with severe disease activity, glomerulonephritis, serositis and hemolytic anemia (p < 0.01). BCMA expression showed a negative correlation with Mex-SLEDAI score (r = -0.494, p = 0.006).Decreased BCMA expression on peripheral B cells according to severe disease activity suggests that BCMA plays an important regulating role in B-cell hyperactivity and immune tolerance homeostasis in SLE patients.
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