Clinical Study of Protection of Amifostine for Patients with Cisplatin-induced Nephrotoxicity using Chemotherapy Again

Objective To observe the protective effect of amifostine on the patients using cisplatin-based chemotherapy again,whose nephrotoxicity had been induced by cisplatin.Methods 19 patients whose renal function had been damaged by cisplatin received cisplatin-based chemotherapy again. Amifostine 250 mg/m2 was used 30 minutes before injection of cisplatin.The indicators included blood urea nitrogen and creatinine being assayed before and after the chemotherapy to observe the amelioration of renal function.Results The total effective rate was 84.2% in the 19 patients,with CR 4 cases,SD 12 cases,PD 3 cases.Conclusion Amifostine used before cisplatin-based chemotherapy can protect the renal function having been damaged by cisplatin from further being destroyed.