化学
区域选择性
亲核细胞
戒指(化学)
环氧化物
组合化学
有机化学
反应条件
催化作用
作者
Furqan Ahmad Saddique,Ameer Fawad Zahoor,Sadia Faiz,Syed Ali Raza Naqvi,Muhammad Usman,Matloob Ahmad
标识
DOI:10.1080/00397911.2016.1170148
摘要
β-Amino alcohols are versatile intermediates in the synthesis of various biologically potent compounds, which can also be achieved by ring opening of epoxides by amines. In the present review, focus has been placed on the ring opening of epoxides with amines under a variety of reaction parameters reported during 2011–2015. All the factors that resulted in excellent yields and high regioselectivity, are environmentally benign, and use mild conditions have been discussed in detail. In addition, the applications of these methods in the synthesis of biologically active compounds such as β-blockers have also been described.
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