Preparation of Bulleyaconitine A microemulsion and investigation of its physicochemical properties

OBJECTIVE To prepare the microemulsion of bulleyaconitine A in order to increase its solubility by using appropriate proportion of oil,surfactant(S),cosurfactant(Cos) and water.The formulation of proportion was optimized.The physicochemical properties of microemulsion was studied.METHODS Pseudo-tertiary phase diagrams were prepared to obtain the concentration ratio of components of microemulsion.Optimized the microemulsion formulation by the size of the microemulsion regin.The partical size and content distribution of the micromulsion was investigated by zetapals zeta potentiall partical size analysis.RESULTS The solubility of bulleyaconitine A in microemulsion was raised.The average droplet size of microemulsion was about 53.6 nm.CONCLUSION The O/W bulleyaconitine A microemulsions is prepared,to support for the development of bulleyaconitine A transdermal preparation.