Changes of Physiological Indexes in Hematopoietic System of Mice after ~(60)Coγ Ray Irradiation

Objective To explore the physiological variation of the hematopoietic system in mice after 60Coγ ray irradiation.Methods Body weight,peripheral blood cell counts,the immune organ index and pathological changes in femoral bone marrow of mice were measured at different times after whole-body irradiation with 60Coγ ray.The doses were 2,4,6 Gy respectively.Results The changes of peripheral blood of mice were different.The white blood cell counts declined most rapidly and obviously,followed by the platelet count,with a dose-effect relationship.Three days after radiation,the immune organ index of mice decreased significantly compared with the immune organ index in mice unirradiated.Myeloid elements in bone marrow were reduced and bone marrow hematopoiesis was depressed.Body weight of irradiated mice grew slowly,without significant difference with mice unirradiated.Conclusion 60Coγ ray radiation can decrease peripheral blood cells,decrease the immune organ index and inhibit bone marrow cell proliferation in mice.