Effect analysis of gemcitabine compared with carboplatin for the treatment in advanced non-small cell lung cancer

OBJECTIVE: To explore the clinical effect of gemcitabine compared with carboplatin treatment in advanced non-small cell lung cancer.METHODS: Totally 98 cases with advanced non-small cell lung cancer were randomly divided into group A(gemcitabine compared with carboplatin) and group B(gemcitabine compared with cisplatin).Group A received gemcitabine of 1 000 mg/m2 on day 1 and 8,and carboplatin of AUC 5 on day 1.Group B were given cisplatin 80 mg/m2 on d1 and 2 based on gemcitabine treatment.Twenty-one days were for a cycle and all the patients received 2 cycles of treatments.Effective rate of treatment,1 year survival rate,adverse reaction rate and life quantity were compared between two groups.RESULTS: Effective rates of treatment were 39.7% and 40.0% in group A and group B respectively(P0.05);There were no significant difference of 1 year survival rate between two groups(52.1% vs 45.0%,P0.05);Grade Ⅲ~Ⅳgastrointestinal effect in group A were much less than that in group B(0 vs 12.5%,P0.05);LCSS scores after treatment in group A were superior to group B(P0.05).CONCLUSIONS: Gemcitabine compared with carboplatin or cisplatin treatment in advanced non-small cell lung cancer achieve the same effectiveness.Gemcitabine compared with carboplatin have less adverse reaction rate,and it is well-tolerated for patients.