Role of NFAT in tumor development and progression

Nuclear factor of activated T cell(NFAT) is an important factor in cellular signal pathways and plays a key role in the immune system as well as tumor development and progression.NFAT is activated mainly by calcium flux;activated-NFAT translocates to nucleus and interacts with target-DNA,regulating the expression of target genes by working together with other co-activators.Different NFAT subtypes have various regulatory effects on tumor cell transformation and proliferation,increasing tumor angiogenesis and infiltration or migration.Further understanding of NFAT expression in tumors,its acting mechanisms,and its roles in tumor development and progression will help to find potential tumor targets for tumor clinical therapy.