The extraction condition of pomegranate polyphenols was optimized by orthogonal experiment.The results showed that extraction temperature,extraction time,ratio of raw material to solvent and ethanol concentration had significant influences on pomegranate polyphenol extraction,of which the ratio of raw material to solvent exhibited the greatest effect on the extraction yield.The optimum extraction condition was as follows: ratio of pomegranate peel powder to ethanol-water(20 %,volume part) 1∶20 at(50℃) for(1h).Under this condition,the yield of polyphenols from pomegranate peel was(22.86%) while the yield of crude(extract) and polyphenol content in the extract were(44.98%) and(50.12%),respectively.