ABSTRACT 331

Background and aims: Sugammadex was synthesized as a selective reversal agent for the neuromuscular blocking agent, rocuronium. Several authors have reported the use of sugammadex and rocuronium in infants, but there have been few reports of its use for laparoscopic pyloromyotomy. Aims: The aim of this study was to investigate the relationship between the dose of sugammadex and rocuronium, time to extubation both after the end of surgery and after administration of sugammadex for laparoscopic pyloromyotomy in infants with hypertrophic pyloric stenosis. Methods: This study was approved by the institutional review board. The data was collected retrospectively from 8 consecutive laparoscopic pyloromyotomy procedures in infants with hypertrophic pyloric stenosis between May 2012 and April 2013. Results: At the time of surgery, the median age was 33 days (range 15–84) and the weight was 3.7 kg (2.9–5.1). The median duration of surgery was 29.5 minutes (23–46). The median doses of sugammadex and rocuronium were 2.2 (1.7–11.3) and 0.83 mg/kg (0.48–2.12), respectively. The time to extubation after surgery was 16 minutes (6–62), and the time to extubation after administration of sugammadex was 10 minutes (5–60). Greater doses of sugammadex were directly associated with greater doses of rocuronium (p=0.013, r2=0.67). Greater doses of sugammadex and rocuronium were associated with longer times to extubation after surgery (p=0.0016, r2=0.83; p=0.0019, r2=0.82) and longer times to extubation after administration of sugammadex (p=0.0037, r2=0.78; p=0.0014, r2=0.84), respectively. Conclusions: Greater doses of sugammadex and rocuronium were related to a longer time to extubation after the end of surgery.