Effects of Bispectral Index-onclosed Loop-target Controlled Infusion with Propofol Sedation and Gastric Acid of ICU Stress Ulcer Patients

Obiective To compare the effects between different bispectral index-closed loop-target controlled infusion with propofol on sedation of ICU critical illness patients,and search the best bispectral index. Methods 30 ICU critical illness patients in EICU were randomly divided into three groups.By closed loop-target controlled infusing propofol feed back with different bispectral index,the BIS of groupsⅠ,Ⅱand Ⅲwere 55～ 65,65～75 and 75～85,respectively.We recorded the Ramsay score,HR,MAP,pH value of gastric acid per-hour and the total dose of propofol with the pre-sedation and after sedation in 24 hours.Results With the decrease of the bispectral index, score of Ramsay changed between 3 to 5; there was no significant difference in gastric acid pH value of the patients between group Ⅱ and Ⅲ (P0.05) while there was significant difference between the group Ⅰand Ⅲ.Compared with the pre- sedation,HR and MAP didn’t change in the group Ⅱand Ⅲafter sedation,while decreased in group Ⅰ (P0.05).The total dose of propofol in group Ⅲ was less than in groupⅠremarkably (P0.05).Conclusion The application of BIS can make good judgement in the sedation . It shoud be choose the individuation sedation proposal according to ICU critical illness patients’different condition.