A glucose-triggered cascade catalytic adhesive hydrogel enables mild photothermal-biofilm eradication for infected diabetic wounds

sealing of moist wound surfaces. Within the hyperglycemic microenvironment, gold nanoclusters catalyze the conversion of glucose into hydrogen peroxide. Under near-infrared irradiation, the plasmonic photothermal effect further converts hydrogen peroxide into highly reactive hydroxyl radicals while depleting endogenous glutathione within bacteria, weakening their antioxidant defenses and enabling effective bacterial eradication and biofilm disruption under mild-temperature conditions without obvious thermal damage to surrounding tissues. Through the synergistic integration of glucose consumption, reactive oxygen species generation, bacterial defense attenuation, and mild photothermal enhancement, STU@Au markedly accelerates infected diabetic wound healing, providing a promising therapeutic strategy for chronic wound management.