Near‐Infrared Upconversion Modulation of Intracellular Protons for Autophagy‐Induced Apoptosis

-triggered biodegradation, restoring the NIR upconversion luminescence (at 800 nm) of UCNPs. Following intravenous administration, the nanoagent achieves a six-fold reduction in tumor weight and elevates proton levels in glioma, effectively triggering PAA under non-invasive NIR irradiation. This work establishes a spatiotemporally controlled platform for intratumoral proton dynamics, enabling precision cancer theranostics.