Recent Advances in Persulfuranyl Transfer Reagents

Abstract The pentafluorosulfanyl (SF5) group has emerged as an attractive motif in drug design, yet access to SF5-containing molecules was long based on toxic or gaseous reagents with limited practicality. In this review, we summarize recent advances in novel SF5 transfer reagents, with emphasis on their design, synthesis, and reactivity. These advances provide a versatile toolkit to advance the accessibility of SF5 incorporation in organic synthesis and medicinal chemistry.