Denitrative Coupling Reaction: A Powerful Synthetic Tool in Functional Transformation

Nitro hydrocarbons as inexpensive, easily available, and relatively stable organic intermediates have aroused great attention in various functional group transformations over the past several decades. The electron-withdrawing action of the nitro group can act as a transient leaving group to efficiently transform into the other important functionalities. Nitro compounds are easily prepared through simple synthetic reactions from simple and facile starting substrates and provide an exciting opportunity for the synthesis of various valuable products. This account will review recent progress in the denitrative coupling reaction of nitroalkanes, nitroolefins, and nitroarenes under transition metalcatalyzed, transition metal-free, or visible light induced conditions.