肠道菌群
免疫系统
多发性硬化
内大麻素系统
神经炎症
免疫学
背景(考古学)
实验性自身免疫性脑脊髓炎
生物
大麻素
疾病
肠-脑轴
炎症性肠病
自身免疫
神经科学
炎症
医学
受体
古生物学
病理
生物化学
作者
Leyre Mestre,Francisco Carrillo‐Salinas,Míriam Mecha,Ana Feliú,Carmen Guaza
标识
DOI:10.1016/j.bcp.2018.08.037
摘要
The gut microbiota plays a fundamental role on the education and function of the host immune system. Immunological dysregulation is the cause of numerous human disorders such as autoimmune diseases and metabolic disorders frequently associated with inflammatory processes therefore is critical to explore novel mechanisms involved in maintaining the immune system homeostasis. The cannabinoid system and related bioactive lipids participate in multiple central and peripheral physiological processes that affect metabolic, gastrointestinal and neuroimmune regulatory mechanisms displaying a modulatory role and contributing to the maintenance of the organism’s homeostasis. In this review, we gather the knowledge on the gut microbiota-endocannabinoids interactions and their impact on autoimmune disorders such as inflammatory bowel disease, rheumatoid arthritis and particularly, multiple sclerosis (MS) as the best example of a CNS autoimmune disorder. Furthermore, we contribute to this field with new data on changes in many elements of the cannabinoid system in a viral model of MS after gut microbiota manipulation by both antibiotics and probiotics. Finally, we highlight new therapeutic opportunities, under an integrative view, targeting the eCBS and the commensal microbiota in the context of neuroinflammation and MS.
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