Aminothiazole derivatives. II. A facile synthesis of condensed 4‐aminothiazole derivatives using α‐bromolactams and thioamides

Abstract The reaction of an α‐bromolactam with a thioamide was found to give a cyclic 4‐aminothiazole derivative. Novel heterocyclic compounds such as 4,5,6,7‐tetrahydrothiazolo[4,5‐ b ]pyridines 10 , 5,6,7,8‐tetrahydro‐4 H ‐thiazolo[4,5‐ b ]azepines 11 , 4,5,6,7,8,9‐hexahydrothiazolo[4,5‐ b ]azocine 12 and 9,10‐dihydro‐4 H ‐thiazolo[4,5‐ b ][1]benzazepines 18 were thus prepared and the utility of this method in the construction of 4‐aminothiazole‐containing compounds was suggested.