部分
氨基酸
位阻效应
谷氨酸
化学
共轭体系
立体化学
聚合物
组合化学
高分子化学
有机化学
生物化学
作者
Shixue Wang,Wenjing He,Chunsheng Xiao,Youhua Tao,Xianhong Wang
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2019-02-26
卷期号:20 (4): 1655-1666
被引量:18
标识
DOI:10.1021/acs.biomac.9b00026
摘要
OEGylation is an attractive approach to modifying poly(amino acid)s. OEG conjugation improves water-solubility of poly(amino acid)s, and confers possible thermal-responsive functionality for the conjugated poly(amino acid)s. Nevertheless, the impact of OEG architecture and the manner in which the OEG moiety interferes with the performances of poly(amino acid)s remain a work in progress. In this study, a series of new linear and Y-shaped OEG-substituted poly(glutamic acid)s were designed and synthesized. It is found that the thermoresponsive behavior of OEGylated poly(glutamic acid)s experiences steric repulsion effect, the strengths of which are architecture and length-dependent, and grows pronounced only when the number of the OEG units is ≥6. Notably, the Y-shaped architecture is able to stabilize the helicity of poly(glutamic acid) backbones, while maintaining higher α-helical conformation than its linear counterparts. In sum, our result indicate that Y-shaped architecture is more appropriate toward OEGylating poly(amino acid)s for biomedical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI