嗜麦芽窄食单胞菌
枯草芽孢杆菌
大肠杆菌
抗菌活性
金黄色葡萄球菌
细胞毒性
化学
乙酸乙酯
微生物学
立体化学
发酵
体外
细菌
生物
生物化学
铜绿假单胞菌
基因
遗传学
作者
Sheng‐Yan Qian,Cailing Yang,Afsar Khan,Rong-Xiang Chen,Mingsong Wu,Tuo Li,Qian Wang,Jianguo Liu,Guiguang Cheng
标识
DOI:10.1080/14786419.2018.1475381
摘要
Two new pyrazinoquinazoline alkaloids, epi-fiscalin D (1) and epi-fiscalin E (2), as well as three known analogues, norquinadoline A (3), quinadoline A (4), and fiscalin C (5), were isolated from ethyl acetate extract of the fermentation broth of Stentrophomonas maltophilia QB-77. The structures of new compounds were elucidated on the basis of extensive spectroscopic data analysis including UV, HRESIMS, and 1D and 2D NMR experiments. All the isolated compounds were tested for their in vitro cytotoxicity against five human cancer cell lines (SMMC-7721, MCF-7, HL-60, SW480, and A-549) and antibacterial activities against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus.
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